| TANG Ya-mei,LI Yi,ZHANG Yin-yin.Clinical analysis and study on the life quality of patients with radiation encephalopathy after radiotherapy of nasopharyngeal cancer in Guangdong Province[J].Chinese Journal of Radiological Medicine and Protection,2005,25(4):336-339 |
| Clinical analysis and study on the life quality of patients with radiation encephalopathy after radiotherapy of nasopharyngeal cancer in Guangdong Province |
| Received:November 09, 2004 |
| DOI： |
| KeyWords:Nasopharyngeal carcer Radiation encephalopathy Quality of life |
| FundProject:广东省卫生厅科研基金资助项目(B2004048) |
| Author Name | Affiliation | E-mail | | TANG Ya-mei | Department of Neurology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China | yameitang@hotmail.cm | | LI Yi | 广州市脑科医院 | | | ZHANG Yin-yin | Department of Neurology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China | | | 郭灵 | 中山大学附属肿瘤医院鼻咽癌科 | | | 刘宜敏 | 510120 广州, 中山大学附属第二医院放疗科 | | | 邢诒刚 | Department of Neurology, The Second Affiliated Hospital, Sun Yat-sen University, Guangzhou 510120, China | |
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| Abstract:: |
| Objective To investigate clinical manifestations and image features(MRI) of radiation encephalopathy (RE) in nasopharyngeal cancer(NPC) patients of Guangdong Province after radiotherapy and to evaluate the life quality of the patients as well as influencing factors in RE. Methods The clinical data of 89 patients of RE were retrospectively reviewed. The life quality was evaluated using the LENT/SOMA scoring system in 33 RE and 34 NPC patients received radiotherapy but without RE, who served as the controls. Results There is significant difference in morbidity in six months between the re-radiotherapy group and the first course radiotherapy group (P<0.05). The initial symptom was varied but mainly showed bulbar palsy. The most common symptoms consisted of bulbar palsy,limb paralysis,sensory abnormality and headache. The magnetic resonance (MR) image showed long T1 and long T2. Patients of the RE group had lower QOL score in the social domain, health and life level (P<0.05) compared with the controls. The results of bivariate correlation statistics shows that there are high correlations between some domain of QOL and headache/ nervous system defect/bulbar palsy(P<0.05), indicating the influence of QOL after the onset of illness. Conclusions The latency of RE is shorter after re-radiotherapy. Radiation encephalopathy negatively affecting some domain of life quality of the patient. The negative effect of bulbar palsy should be taken into account. |
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