| DAI Guang-fu,JIN Yue-ying,KOU Ming-ying.An experimental study of microdistribution of 99mTc-DTPA at cellular level[J].Chinese Journal of Radiological Medicine and Protection,2005,25(4):319-321 |
| An experimental study of microdistribution of 99mTc-DTPA at cellular level |
| Received:February 16, 2005 |
| DOI： |
| KeyWords:Cell level Microautoradiography Radiomedicament Argent grain 99mTc-DTPA |
| FundProject:国家自然科学基金资助项目(10375091) |
| Author Name | Affiliation | | DAI Guang-fu | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | JIN Yue-ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | KOU Ming-ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | 苑淑渝 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China | | 张良安 | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Tianjin 300192, China |
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| Abstract:: |
| Objective Traditional MIRD method for dose assessment in nuclear medicine assumes that radionuclide is homogeneously distributed in organs, and the dose to cells and cell nucleus is presented by mean dose to the organ. This project will provide the basic method and data for planning diagnosis and treatment in nuclear medicine, for predicting and evaluating effect and risk of radio-pharmaceuticals, and for further research of microdosimetry at molecular level in nuclear medicine and biology. Method The article will describe the microdistribution of 99mTc-DTPA using microautoradiography and frozen sectioning technique. Results To describe the relationship between argent grain density and nuclide radioactivity a regression curve was depicted and the R value was calculated to be 0.9915. The grain density over cytoplasm was 1.78 times higher than that over nucleus in these cells. Conclusion The distribution of radiomedicament at cellular level is nonuniform.; |
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