| ZHANG Xia,JI Hong-bing,CHEN Zhong-hua.Lung cancer radiosensitization by CMNa in vitro and in vivo[J].Chinese Journal of Radiological Medicine and Protection,2005,25(4):316-318 |
| Lung cancer radiosensitization by CMNa in vitro and in vivo |
| Received:February 28, 2005 |
| DOI： |
| KeyWords:CMNa Lung Cancer γ-knife Radio-sensitization |
| FundProject:国家自然科学基金资助项目(30400524);福建省创新人才专项基金资助项目(2004J065) |
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| Abstract:: |
| Objective To probe into the radiosensitization effect of CMNa on lung tumor cell lines after γ_irradiation combined with γ-knife to treat patients suffering from lung cancer. Methods 1.Cells of small cell lung cancer cell line NCI-H446 and non-small cell lung cancer cell line NCI-H596 irradiated with 60Coγ_rays combined with or without CMNa were counted using trypan blue exclusion methods, and cell survival rate curves were depicted. 2. Patients suffering from lung cancer at different clinical stages were treated using γ-knife combined with or without CMNa, and the curative effect was evaluated 6 weeks after one cycle of treatment. Results CMNa could significantly increase the sensitivity of lung cancer cell lines to γ_irradiation. Curative effect increased significantly by γ-knife treatment combined with CMNa i.e.,the CR+PR rates for these two groups were 47.22% and 37.67% separately(P<0.05), and the tumor inhibition rates were 55.42% and 44.15% separately(P<0.05). These effects were not correlated with clinical stage and pathological type of cancer (P>0.05). Conclusion CMNa could significantly increase the radiation sensitivity of lung cancer cell line cells in vitro and tumors in vivo, therefore,it could be used as a radiosensitization agent in clinical treatment of lung cancer.; |
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