| YAN Yu-qiu,SUN Wei-jian,ZHOU Ping-kun.Antitumor and radiosensitizing effects of phenothiazines on human glioma cell line U-251[J].Chinese Journal of Radiological Medicine and Protection,2005,25(4):305-307 |
| Antitumor and radiosensitizing effects of phenothiazines on human glioma cell line U-251 |
| Received:December 09, 2004 |
| DOI： |
| KeyWords:Glioma Trifluoperazine Phenothiazine Radiosensitizing effect |
| FundProject:国家863计划资助项目(2004AA221160) |
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| Abstract:: |
| Objective To observe the antitumor activity and radiosensitizing effects of phenothiazines in vitro. Methods Trifluoperazine(TFP) and phenothiazine were put in the medium of cultured U-251 cells. Clon-forming ability assay and flow cytometry assay were used. Results Growth restrain was observed in U-251 cells when administered with different doses of TFP and phenothiazine. The effect of TFP was more significant than that of phenothiazine. TFP increased the radiosensitivity of U-251 cells and 20 μmol/L of it could inhibite the G2/M arrest of U-251 cells at 6 h post 4 Gy irradiation. Conclusion TFP has the ability to suppress U-251 cell growth in vitro, and the enhance the radiosensitivity of this cell line. |
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