| LU Xue-guan,LIU Zhi-yong,ZHANG Li-yuan,et al.Clinical analysis of post-irradiation sensorineural hearing loss in patients suffering from nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2005,25(3):264-266 |
| Clinical analysis of post-irradiation sensorineural hearing loss in patients suffering from nasopharyngeal carcinoma |
| Received:July 05, 2004 |
| DOI： |
| KeyWords:Nasopharyngeal neoplasms Radiotherapy Drug therapy Prognosis Sensorineural hearing loss |
| FundProject: |
| Author Name | Affiliation | | LU Xue-guan | Department of Radiation Oncology, The Second Hospital Affiliated to Suzhou University, Suzhou 215004, China | | LIU Zhi-yong | 215004, 苏州大学附属第二医院耳鼻咽喉科 | | ZHANG Li-yuan | Department of Radiation Oncology, The Second Hospital Affiliated to Suzhou University, Suzhou 215004, China | | 田野 | Department of Radiation Oncology, The Second Hospital Affiliated to Suzhou University, Suzhou 215004, China |
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| Abstract:: |
| Objective To investigate the incidence of post-irradiation sensorineural hearing loss(SNHL) in patients suffering from nasopharyngeal carcinoma and to evaluate its potentially contributing factors. Methods (Pure tone )test and impedance audiography were carried out in patients suffering from nasopharyngeal carcinoma with a post-irradiation follow-up time over 1 year.Additionally,the test results were combined with clinical data and analyzed retrospectively. Results The follow-up time of all patients ranged from 12 to 94 months(median 53 months).The incidences of SNHL at low and high frequencies were 8% and 42% respectively.Univariate analysis showed that patient's age and follow-up time affected the incidence of SNHL at high frequencies(t=2.051,P=0.0269;t=2.978,P=0.0011),but sex,preirradiation subjective hearing loss,irradiation dose and chemotherapy including cisplatin had no significance.Multivariate analysis by Binary Logistic Regression revealed that the risk of SNHL was correlated with patient's age and follow-up time (P=0.02;P=0.009). Conclusion Post-irradiation SNHL at high frequencies in patients suffering from nasopharyngeal carcinoma is more common than that at low frequencies.The independent prognostic factors for development of SNHL at high frequencies are patient's age and follow-up time.But the role of preirradiation hearing level,irradiation dose and chemotherapy including cisplatin are not conclusive and further research is needed. |
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