| LIANG Li,ZHANG Shu-lan,ZHANG Zhao-hui,et al.Comparative analyses of the effect of radiotherapy and chemotherapy or chemotherapy alone on patients' electrocardiogram.[J].Chinese Journal of Radiological Medicine and Protection,2005,25(3):262-264 |
| Comparative analyses of the effect of radiotherapy and chemotherapy or chemotherapy alone on patients' electrocardiogram. |
| Received:March 17, 2005 |
| DOI： |
| KeyWords:Cardiotoxicity Radiotherapy Epirubicin Paclitaxel |
| FundProject: |
| Author Name | Affiliation | | LIANG Li | Center of Oncology, Third Hospital of Peking University, Beijing 100083, China | | ZHANG Shu-lan | Center of Oncology, Third Hospital of Peking University, Beijing 100083, China | | ZHANG Zhao-hui | Center of Oncology, Third Hospital of Peking University, Beijing 100083, China | | 王俊杰 | Center of Oncology, Third Hospital of Peking University, Beijing 100083, China | | 贾廷珍 | Center of Oncology, Third Hospital of Peking University, Beijing 100083, China |
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| Abstract:: |
| Objective To investigate the change of breast cancer patients' electrocardiogram during combined radiotherapy and chemotherapy or chemotherapy alone for the sake of predicting the cardiotoxictiy of combined radiotherapy and chemotherapy. Methods From January, 1998 to June, 2004, 47postoperative breast cancer patients were enrolled. Among them 29 patients received chemotherapy combined with radiotherapy (combinative group), and 18 patients received chemotherapy alone (non combinative group). The changes of electrocardiogram were observed and correlation factors were analyzed. Results Abnormal electrocardiograms were noted in 11 (37.9%) and 2 patients(11.1%) of the combinative group and the non-combinative group respectively(z=-1.977,P=0.048). In the combinative group, heart events were significantly increased in patients above 60 years old (z=-2.094 P=0.036). The changes of electrocardiogram were not significantly correlative with hypertension history, tumor site, dose of radiotherapy or chemotherapeutic drugs. But the incidence of abnormal electrocardiogram was higher in patients with a hypertension history than in those without it (54.5% vs 27.8%). Conclusion The abnormalities of electrocardiogram were are more frequent in patients treated with both raditiotherapy combined with chemotherapy. Our results suggest that breast cancer patients should be regularly reexamined with electrocardiography during therapy, especially whose age was those have a hypertension history and above 60 years old. |
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