| LI Rong-qing,JIN Ye-ning,WANG Ya-jie.Clinical outcome and cosmetics in breast cancer patients treated with conservative surgery and radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2005,25(3):256-259 |
| Clinical outcome and cosmetics in breast cancer patients treated with conservative surgery and radiotherapy |
| Received:November 15, 2004 |
| DOI： |
| KeyWords:Breast cancer Radiotherapy Conservative surgery Cosmetic result Brachytherapy |
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| Abstract:: |
| Objective To evaluate the effectiveness and the cosmetics result of radiotherapy after conservative surgery for early breast cancer. Methods Altogether 109 patients were treated by post-operative whole-breast irradiation and a tumor bed boost from May, 1995 to December,2002.Among them 79 cases received a brachytherapy boost (192Ir HDR implant Nucletron ) of 10-12 Gy(DB) by single plan of implantation with 1.5 cm between the needles for T1 and double plan for T2-4 tumors, and 30 cases received an electron beam boost with 15 Gy. External beam irradiation was applied to the whole breast with 45-52 Gy(mean 48.6 Gy)in 25 fractions over 5 weeks followed or concurrently with chemotherapy (CMF or CEF) and hormonotherapy. The cosmetic result was scored by a doctor and patients via questionnaire. Results The median follow-up time was 52 months. The actuarial 5-year overall survival rate was 93.8% using Kaplan-Meier method and the within breast recurrence rate was 6.5%. No radiation- induced ulcer in the breast occurred except acute inflammation of skin around the pinholes in 5 patients. Cosmetic results were scored to be good by patients and the doctor (81% and 87%,respectively) for 75 followed-up cases, and good cosmetic rate was reported by the doctor for 82% (39/48) of the cases treated with brachytherapy boost and 85.2%(23/27) for those treated with external beam boost. There was no difference in cosmetic results between these two groups(P> 0.05). Conclusion In patients at high risk for local recurrence, tumor-bed boost with brachytherapy or electron beam carried out after limited surgery and external radiotherapy can provide satisfactory local control without morbidity. Cosmetic result may not be influenced by the boost technique. |
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