| LI Jian,WANG Ren-sheng,GAN Lang-ge,et al.Radiation-induced neck fibrosis in patients with nasopharyngeal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2005,25(3):253-255 |
| Radiation-induced neck fibrosis in patients with nasopharyngeal carcinoma |
| Received:April 12, 2004 |
| DOI： |
| KeyWords:Nasopharyngeal carcinoma Radiotherapy Neck Fibrosis Radiation damage |
| FundProject: |
| Author Name | Affiliation | | LI Jian | Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | WANG Ren-sheng | Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | GAN Lang-ge | Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | 刘文其 | Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China | | 张勇 | Department of Radiation Oncology, The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China |
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| Abstract:: |
| Objective To investigate the post-irradiation neck fibrosis in patients with nasopharyngeal carcinoma and its related factors. Methods A total of 267 patients received conventional fractionated radiotherapy with D_T50-72 Gy on the neck a half year to 10 years ago were observed for the changes of cervical shape and functions. Results Different degrees of post-irradiation neck fibrosis were seen in all patients. The rate of heavy degree of neck radiation fibrosis was 24.34%,and it was 2.74% when received preventive dose on the neck. There was a very significant difference between patients who received late course of tangential irradiation on the neck and those who didn't receive (P=0.0001).The incidence of post-irradiation neck fibrosis didn't increase when patients received radiotherapy combined with chemotherapy(P=0.2678).The function of cervical muscles turned weak in patients received radiotherapy delivered by 6 MV accelerator in late course of tangential irradiation, whereas skin damage was severer in patients treated with 60Coγ-rays. Conclusion The incidence of heavy degree of post-irradiation neck fibrosis is high,and is related closely to late course of tangential irradiation. We should avoid adopting this sort of irradiation on the neck. |
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