| FANG Heng-hu,ZENG Gui-ying,REN Dong-qing.Study on ultrastructural changes of the pituitary gland in rats exposed to pulsed electromagnetic fields (PEMF)[J].Chinese Journal of Radiological Medicine and Protection,2005,25(2):175-177 |
| Study on ultrastructural changes of the pituitary gland in rats exposed to pulsed electromagnetic fields (PEMF) |
| Received:January 18, 2005 |
| DOI： |
| KeyWords:Pulsed electromagnetic fields (PEMF) Rat Pituitary gland Ultrastructure |
| FundProject: |
| Author Name | Affiliation | E-mail | | FANG Heng-hu | Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China | gyzeng@fmmu.edu.cn | | ZENG Gui-ying | Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China | | | REN Dong-qing | Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China | | | 金成 | Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China | | | 黄晓峰 | 710032 西安, 第四军医大学预防医学系电子显微镜中心 | | | 郭鹞 | Department of Radiation Medicine, Faculty of Preventive Medicine, Fourth Military Medical University, Xi’an 710032, China | |
|
| Hits: 2902 |
| Download times: 1674 |
| Abstract:: |
| Objective To observe the effects of exposure to PEMF on ultrastructure of pituitary gland of rats. Methods Altogether 30 male SD rats were randomly divided into five groups, one for sham and the others for PEMF exposure(200 kV/m, 200 times) pulses. After exposure, the rats were scacrificed and pituitary glands were taken out at different time points(6, 12, 24 and 48h). Ultrastructural changes of the prepared samples were observed under a transmission electron microscope. Results At 6 h after PEMF exposure, swollen mitochondria with cristae loss, dilatation of Golgi complex and diffused lysosomes were found in endocrine cells of pituitary gland, especially in lactotrophic cells and growth hormone_secreting cells. These changes were gradually aggravated, mitochondrial vacuolization and forming of myelin figures, distinct dilatation of endoplasmic reticulum, occurrence of numerous secondary lysosomes and gathering of heterochromatins under nuclear membranes could be observed at 48 h. Conclusions PEMF may damage endocrine cells in anterior lobe of pituitary gland of rats. Mitochondria and endoplasmic reticulum are the sensitive organelles to PEMF. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
