| FENG wei,ZHU Shu-chai,LI ren.Analyzing predictors of radiation-induced esophageal toxicity in patients with stage Ⅲ unresectable non-small cell lung cancer treated with three-dimensionalconformal radiotherapy.[J].Chinese Journal of Radiological Medicine and Protection,2005,25(2):147-150 |
| Analyzing predictors of radiation-induced esophageal toxicity in patients with stage Ⅲ unresectable non-small cell lung cancer treated with three-dimensionalconformal radiotherapy. |
| Received:March 18, 2004 |
| DOI： |
| KeyWords:Non-small cell lung cancer Conformal radiotherapy Radiation esophagitis |
| FundProject:河北省自然科学基金资助项目(301393) |
| Author Name | Affiliation | E-mail | | FENG wei | Department of Radiation Oncology, the Fourth Hospital, Hebei Medical University. Shijiazhuang 050011, China | fengweibraian@sohu.com | | ZHU Shu-chai | Department of Radiation Oncology, the Fourth Hospital, Hebei Medical University. Shijiazhuang 050011, China | | | LI ren | Department of Radiation Oncology, the Fourth Hospital, Hebei Medical University. Shijiazhuang 050011, China | | | 邱嵘 | Department of Radiation Oncology, the Fourth Hospital, Hebei Medical University. Shijiazhuang 050011, China | | | 李娟 | Department of Radiation Oncology, the Fourth Hospital, Hebei Medical University. Shijiazhuang 050011, China | | | 王玉祥 | Department of Radiation Oncology, the Fourth Hospital, Hebei Medical University. Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective To evaluate clinical and dosimetric predictors of acute and late esophageal toxicity in patients with stage Ⅲ non-small-cell lung cancer (NSCLC) treated with three-dimensional conformal radiotherapy(3D-CRT).Methods We retrospectively reviewed 56 patients with NSCLC who were treated with 3D-CRT between August 2000 and December 2002. The clinic factors and treatment parameters were collected and coded.Acute and late esophageal toxicities were graded. All factors correlating with acute and late esophageal toxicity were analyzed. Results 24 patients (42.8%) developed acute esophageal toxicity, 7 patients(12.5%) developed late esophageal toxicity,according to RTOG scores, the acute esophageal toxicities were graded: Ⅰ-14、Ⅱ-5、Ⅲ-5; late esophageal toxicity were graded :Ⅰ-2、Ⅱ-1、Ⅲ-4. Spearman rank correlation coefficients showed that chemotherapy, percentages of esophagus volume receiving >50Gy(V50 ), the average dose to the esophagus, correlated with acute esophageal toxicity, and the gross tumor volume (GTV),the fraction of radiotherapy were significantly correlated with late esophageal toxicity. Binary Logistic regression analysis showed chemotherapy, esophageal V50,were the independent risk factors of acute esophageal toxicity. Esophageal NTCP and GTV were the independent risk factors of late esophageal toxicity. There were not relation between the survival ratio and acute,late esophageal toxicity. Conclusions In stage III NSCLC patients treated with 3D-CRT, chemotherapy and esophageal V50 were significantly associated with a risk of acute esophageal toxicity; esophageal NTCP and GTV were the independent risk factors of late esophageal toxicity. |
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