| CHEN Shan-yi,LI Xian-ming,WU Dong.The influence of bolus on the radiation-induced skin disorders and the local regional control rate[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):65-67 |
| The influence of bolus on the radiation-induced skin disorders and the local regional control rate |
| Received:September 23, 2004 |
| DOI： |
| KeyWords:Naropharyngeal neoplasm Radiotherapy Bolus Percentage depth dose |
| FundProject: |
| Author Name | Affiliation | | CHEN Shan-yi | Department of Radiation Oncology, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen 518020, China | | LI Xian-ming | Department of Radiation Oncology, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen 518020, China | | WU Dong | Department of Radiation Oncology, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen 518020, China | | 闫茂生 | Department of Radiation Oncology, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen 518020, China | | 任浙平 | Department of Radiation Oncology, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen 518020, China | | 胡岳然 | Department of Radiation Oncology, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen 518020, China | | 吴超权 | Department of Radiation Oncology, Second Affiliated Hospital, Medical College of Jinan University, Shenzhen 518020, China |
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| Abstract:: |
| Objective To study the severity of radiation-induced skin disorders and local regional control rate in nasopharyngeal carcinoma(NPC) with the using of bolus on the neck. Methods From June, 2000 to December, 2001, 90 patients with pathologically confirmed NPC(stage Ⅱ-Ⅳa ) and without using any kind of anti-tumor treatment previously were randomly assigned into 3 groups:1.no bolus,2.bolus with 0.5 cm thick, 3. bolus with 1.0 cm thick. Radiotherapy was applied by using cerrobend block via-faciocervical portal at isocentre in whole cervical region with 50 Gy/25 fractions in 5 weeks,then removed the bolus and reduced field boost to 20 Gy for 2 weeks. For all patients, the percentage depth dose (PDD) at the surface of neck skin and the metastatic mass surface was caculated.The short- and long-term (2 years) clinical outcome,acute and late radiation sequelae were observed. Results Compared with group 1, there was significant additional dose increase at the surface of the skin in groups 2 and 3.The PDD increased over 100% in both groups [In 1,2 and 3 groups, it was (42.54±2.38)%,(86.03±1.23)% and (97.77±0.24)%, respectively],whereas the elevation of PDD at the metastatic mass surface was less than 6% [In 1,2 and 3 groups it was (94.58±5.19)%,(99.80±0.38)% and (98.91±1.37)%, respectively].The acute and late radiation sequelae for group 1 were better than groups 2 and 3 (P=0.000), while for the short- and long-term control rate of the cervical lymph node metastasis there was no significant difference among them (P>0.05). Conclusion Unless the skin is invaded, it is not necessary to put bolus on the cervical skin in NPC radiotherapy. |
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