| GAO Xian-shu,ZHOU Zhi-guo,QIAO Xue-ying,et al.A preliminary report of 7-day continuous accelerated irradiation in patients with esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):59-62 |
| A preliminary report of 7-day continuous accelerated irradiation in patients with esophageal carcinoma |
| Received:June 26, 2004 |
| DOI： |
| KeyWords:Esophageal cancer Radiotherapy Accelerated fractionation Toxicity Overall treatment time |
| FundProject: |
| Author Name | Affiliation | E-mail | | GAO Xian-shu | Department of Radiation Oncology, 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China | gaoxs@heinfo.net | | ZHOU Zhi-guo | Department of Radiation Oncology, 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | QIAO Xue-ying | Department of Radiation Oncology, 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | 杨香然 | Department of Radiation Oncology, 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | 张钧 | Department of Radiation Oncology, 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China | | | 万钧 | Department of Radiation Oncology, 4th Hospital of Hebei Medical University, Shijiazhuang 050011, China | |
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| Abstract:: |
| Objective Toxicity of the 7-day continuous accelerated irradiation schedule (CAIR) was evaluated and compared with the late course accelerated hyperfractionation radiotherapy schedule (LCAF) for esophageal carcinoma in a randomized trial. Methods Fifty-seven patients with squamous cell carcinoma of esophagus were randomly enrolled into two groups: 29 to the CAIR group and 28 to the LCAF group. In CAIR group the dose per fraction of 2.0 Gy was given once a day at 24 h intervals and the overall treatment time was 4.2 weeks (30 days). The patients in the LCAF group received conventional fractionation radiotherapy, at 2 Gy/fraction, to a dose of 30 Gy in 15 fractions during 3 weeks, followed by accelerated fractionation radiotherapy, b.i.d., at 1.5 Gy/fraction, with a minimal interval of 6 h between fractions, and the overall treatment time was 5 weeks. The total dose was 60 Gy in both groups. Results More serious acute esophagitis was observed in CAIR group than that in LCAF group, and the incidences of grade Ⅲ esophagitis were 31.0% and 14.3%, respectively. The late effect was not more frequent in CAIR group than in the LCAF group, the incidences of grade Ⅴ esophageal late effect were 10.3% and 7.1%, and the 1-year survival rates were 66.14% and 64.72%,respectively in CAIR group and LCAF group. Conclusion Although the higher incidences of severe acute reactions were observed in CAIR group, the patients could tolerate the effects and complete this treatment. |
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