| XIE Liang-xi,LI De-rui,LIN Kun.Arsenic trioxide (As2O3) enhances radiosensitivity of nasopharyngeal carcinoma in vivo[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):49-52 |
| Arsenic trioxide (As2O3) enhances radiosensitivity of nasopharyngeal carcinoma in vivo |
| Received:October 27, 2003 |
| DOI： |
| KeyWords:Nasopharyngeal neoplasm Radiotherapy Arsenic trioxide Radiation sensitizing agent |
| FundProject:国家中医药管理局专项基金资助项目(0405LL10);广东省中医药局科研基金资助项目(102053);汕头大学研究和发展基金资助项目(L03002) |
| Author Name | Affiliation | | XIE Liang-xi | Department of Radiation Oncology, Cancer Hospital, Shantou University Medical College, Shantou 515031, China | | LI De-rui | Department of Radiation Oncology, Cancer Hospital, Shantou University Medical College, Shantou 515031, China | | LIN Kun | 汕头大学医学院卫生学教研室 | | 陈炯玉 | 515031 汕头, 大学医学院中心实验室 | | 洪超群 | 515031 汕头, 大学医学院中心实验室 |
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| Abstract:: |
| Objective To determine whether As2O3 could enhance the radiosensitivity of nasopharyngeal carcinoma(NPC)in vivo. Methods BALB/c mice bearing NPC xenografts,CSNET-1,were randomized into control and experimental groups.As2O3 at a dosage of 4 mg/kg body weight was administered i.p. for consecutive 6 days to the experimental group.On the 7th day,the BALB/c mice in the experimental group were given 0 Gy,2 Gy,4 Gy and 6 Gy of X-irradiation,respectively.The volumes of the transplanted tumors were then measured twice a week until reaching at least 4 times of the initial volumes.Tumor growth delay and radiosensitizer enhance ratio were calculated. Results In vivo study showed that As 2O\-3 could inhibit the growth of the xenograft tumors.The SER were 1.55,1.71,and 1.77 for the tumor growth delay time of 4,8,12 days,respectively.No severe toxicity was observed in the mice either by biochemical or by histological examination. Conclusion As\-2O\-3 is a potential radiosensitizer for nasopharyngeal carcinoma in vivo. |
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