| LI Yi,WANG Hai-qing.Effect of carrageenan-derived oligosaccharides on T cell function and subsets in irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):41-42 |
| Effect of carrageenan-derived oligosaccharides on T cell function and subsets in irradiated mice |
| Received:April 25, 2004 |
| DOI： |
| KeyWords:Carrageenan-derived oligosaccharide Irradiation-induced injury T-cell function CD4+/CD8+ |
| FundProject:山东省攻关计划基金资助项目(031070120) |
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| Abstract:: |
| Objective To observe the effect of carrageenan-derived oligosaccharides on T cell function and subsets in irradiated mice. Methods The carrageenan-derived oligosaccharides were applied to BALB/c mice for 14 successive days before and 7 days after whole body irradiation with 6.0 Gy X-rays. The transformation response of splenic lymphocyte,the expression of CD69 in thymocytes,IL-2,IFN-γ and TNF-α in T-cells of PBMC,and CD4+/CD8+ ratio of T lymphocytes were evaluated. Results The carrageenan-derived oligosaccharides increased ConA-stimulated transformation of splenic T lymphocytes of mice,characterized by marked up-regulation of CD69 expression in thymic lymphocytes,significantly enhanced the ability of PBMC to produce IL-2 and IFN-γ,decreased the expression of TNF-α in T-cells of PBMC,and over-expressed CD+ 4 in T lymphocytes,followed by increment in CD4+/CD8+ ratio of T lymphocytes. Conclusion Carrageenan-derived oligosaccharides can markedly adjust T cell function and subsets in irradiated mice. |
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