| WANG Yue-ying,WANG Ru-qin,ZHAO Zhong-ping.Radiation protective effects of four kind of estrogens on mice[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):39-40 |
| Radiation protective effects of four kind of estrogens on mice |
| Received:June 28, 2004 |
| DOI： |
| KeyWords:E838 EE2 EE3 E3 Irradiation Survival rate Estrogen activity |
| FundProject:天津市自然科学重点基金资助项目(043802411) |
| Author Name | Affiliation | | WANG Yue-ying | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | WANG Ru-qin | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China | | ZHAO Zhong-ping | Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Peking Union Medical College, Tianjin 300192, China |
|
| Hits: 2617 |
| Download times: 1623 |
| Abstract:: |
| Objective To observe the radioprotective effect of E838 , ethinyl estradiol (EE2 ), ethinyl estriol (EE3 ), estrio (E3 ) on survival rate of KM mice irradiated with 8.0 Gy γ-rays,and compare estrogen activities of E838 and EE2 . Methods Five groups of KM mice were injected intraperi-toneally with E838 ,EE2 ,EE3 ,E3 and tea oil (control group) respectively at 36 h or during 3 succesive days before irradiation. The doses were 25 μg for E838 , EE2 , 100 μg for EE3 and E3 per mouse.Female mice of 18 days old were injected with E838 and EE2 on 3,2 and 1 before irradiation. The radiation dose was 8 Gy 137Cs γ-rays with dose rate 1 Gy/min. Results The 30-day survival rate of mice injected with E838 on 3,2 and 1 before irradiation was the highest,and the averaged survival rate was 33.9% higher than that of the control group. The estrogen activity of E838 was low. Conclusion E838 is an effectively protective drug aganist radiation. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
