| WANG Zhi-dong,CHEN Xiao-hua,DONG Bo,et al.Research on the expression of haptoglobin in bone marrow of irradiated mice[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):31-34 |
| Research on the expression of haptoglobin in bone marrow of irradiated mice |
| Received:October 18, 2004 |
| DOI： |
| KeyWords:Ionizing radiation Haptoglobin Bone marrow |
| FundProject:全军“十五”指令性课题基金资助项目(01L018) |
| Author Name | Affiliation | E-mail | | WANG Zhi-dong | Beijing Institute of Radiation Medicine, Beijing 100850, China | chenxh@nic.bmi.ac.cn | | CHEN Xiao-hua | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | DONG Bo | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 张军权 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 饶亚岚 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 高荣莲 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 侯丽莉 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | | 毛秉智 | Beijing Institute of Radiation Medicine, Beijing 100850, China | |
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| Abstract:: |
| Objective To study the expression and distribution of the haptoglobin in the bone marrow of irradiated mice and explore the relationship between haptoglobin and cell cycle or apoptosis. Methods RT-PCR and Western blot were adopted to respectively detect the changes of the haptoglobin at mRNA and protein levels. Flow cytometry (FCM) was applied to analyze the relation between cytoplasmic haptoglobin existence in bone marrow and cell cycle or apoptosis. Results The results showed that increased levels of haptoglobin mRNA and protein were present after irradiation. Results of FCM indicated there was difference in cell cycle between the cells with and without haptoglobin protein. Conclusion Haptoglobin might be involved in the repair process of radiation injury. |
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