| WU Ning,SUN Han-ying,LIU Wen-li,et al.Expression of bFGFR,Flt-1 in murine bone marrow mononuclear cells with radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):25-26 |
| Expression of bFGFR,Flt-1 in murine bone marrow mononuclear cells with radiation injury |
| Received:February 27, 2004 |
| DOI： |
| KeyWords:Irradiation Bone marrow bFGFR Flt-1 |
| FundProject:国家自然科学基金资助项目(39870926) |
| Author Name | Affiliation | | WU Ning | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China | | SUN Han-ying | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China | | LIU Wen-li | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China | | 孟凡凯 | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China | | 李春蕊 | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China | | 何莉 | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030 Wuhan, China |
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| Abstract:: |
| Objective To analyse the expressions of bFGFR,Flt-1 in mice bone marrow mononuclear cells(BMMNC) after exposure to γ-radiation. Methods Kunming strain mice irradiated with 6.0 Gy 60Co γ-rays were used to analyse the bFGFR and Flt-1 expression in BMMNC by flow cytometry on days 3,7 and 14 after irradiation. Results Expressions of bFGFR,Flt-1 in BMMNC after irradiation were significantly lower than those in normal BMMNC (t=2.33-6.35 and 4.14-20.61;P<0.05 and P<0.01,respectively). Their expressions were still lower on day 14(t=2.33 and 4.17;P<0.05 and P<0.01,respectively). The expressions of bFGFR,Flt-1 in BMMNC showed direct correlation(r=0.5533,P<0.05). Conclusion γ-radiation inhibits bFGFR,Flt-1 expressions in BMMNC,suggesting that the abnormal expressions of bFGFR,Flt-1 in BMMNC are involved in the injury of hematopoietic microenvironment(HIM) by γ-radiation. |
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