| GUO Ping\,WANG Ji-feng,WANG Sheng-qi.Effects of 3.5 Gy γ-rays on protein expression of mouse bone marrow[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):18-20 |
| Effects of 3.5 Gy γ-rays on protein expression of mouse bone marrow |
| Received:June 28, 2004 |
| DOI： |
| KeyWords:Irradiation Bone marrow Functional proteomics |
| FundProject:国家自然科学基金资助项目(30271617);军队“十五”重点项目(01Z019);北京市“二四八”重大创新工程项目(H010210220113) |
|
| Hits: 3294 |
| Download times: 1988 |
| Abstract:: |
| Objective To observe the effects of γ-rays on protein expression of mouse bone marrow,in order to provide theoretical and experimental basis for understanding the molecular mechanism of bone marrow injury caused by radiation. Methods Bone marrow injury models were established by irradiation with 3.5 Gy 60Co γ-rays.With proteomic technology,the proteins of bone marrow were isolated,analyzed and identified. Results Irradiation with 3.5 Gy γ-rays caused up-regulation of 18 kinds of bone marrow proteins in mice and down-regulation of 6 proteins,most of them being associated with growth and differentiation of cells. Conclusion Irradiation with 3.5 Gy γ-rays can affect protein expression of bone marrow and thus inhibit its hematopoiesis. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
