| LI Hua-jie,BAO Shi-yao,TIAN Ye.The neuroprotective effect of NBQX on oligodendrocyte precursor cells in rat cerebral cortex after whole brain irradiation[J].Chinese Journal of Radiological Medicine and Protection,2005,25(1):9-12 |
| The neuroprotective effect of NBQX on oligodendrocyte precursor cells in rat cerebral cortex after whole brain irradiation |
| Received:February 28, 2004 |
| DOI： |
| KeyWords:Ionizing radiation Oligodendrocyte precursor cells NBQX |
| FundProject:国家自然科学基金资助项目(30170287) |
| Author Name | Affiliation | E-mail | | LI Hua-jie | Neurology Department of The Second Affiliated Hospital, Suzhou University, Suzhou 215000, China | baishiyao@pulicl.sz.js.cn | | BAO Shi-yao | Neurology Department of The Second Affiliated Hospital, Suzhou University, Suzhou 215000, China | | | TIAN Ye | Neurology Department of The Second Affiliated Hospital, Suzhou University, Suzhou 215000, China | | | 吴莹 | Neurology Department of The Second Affiliated Hospital, Suzhou University, Suzhou 215000, China | |
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| Abstract:: |
| Objective To explore the early phase radioresponse of oligodendrocyte precursor cells in ratcerebral cortex after whole brain irradiation and the protective effect of MK801 and NBQX. Methods MK801 (5 mmol/L) or NBQX(50 mmol/L) was injected into the cerebral cortex of SD rats by using a stereo-directional instrument after whole brain irradiation at dose of 10 Gy.Then NG2 and O4-positive cells in the cortex were determined at each time-point by immunofluorescence histochemistry. Results The numbers of NG2 and O4-positive cells in the cortex of rats in the irradiation group increased significantly on day 7 after irradiation as compared with those in the sham irradiation group (P<0.05).There was no obvious difference for the number of NG2 or O4-positive cells in the cortex between rats of the MK801 group and the irradiation group (P>0.05).The numbers of NG2 and O4-positive cells in the cortex of rats in the NBQX group were significanctly higher on days 1 and 7 than that those of rats in the irradiation group (P<0.05). Conclusion The number of oligodendrocyte precursor cells in the cortex of rats increases reactively in the early phase after whole brain irradiation and has alteration with observing time-point.And NBQX has some neuroprotective effect on oligodendrocyte precursor cells in the early phase of radiation injury. |
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