| ZHEN Rong,ZHENG Hui,LIAO Jinghui,et al.Promotion of immunologic function recovery in γ-irradiated mice by ginsenosides[J].Chinese Journal of Radiological Medicine and Protection,2004,24(6):545-547 |
| Promotion of immunologic function recovery in γ-irradiated mice by ginsenosides |
| Received:May 24, 2004 |
| DOI： |
| KeyWords:Ginsenosides CD4 and CD8 T lymphocyte Delayed hypersensitivity(DTH) NK killer cell activity T lymph cell transformation ability IL-2 γ-ray irradiation |
| FundProject: |
| Author Name | Affiliation | | ZHEN Rong | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | ZHENG Hui | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | LIAO Jinghui | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | 涂序珉 | National Institute for Radiological Protection, China CDC, Beijing 100088, China | | 封江彬 | National Institute for Radiological Protection, China CDC, Beijing 100088, China |
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| Abstract:: |
| Objective To investigate the effect of promoting immunologic function recovery by ginsenosides in gammairradiated mice. Methods Mice were irradiated with gamma rays（7 Gy）to establish an animal model of hypoimmunity.Ginsenosides was given in 10 days at the dosage of 87.5 mg·kg -1 both before and after irradiation.The NK killer cell activity,T lymphocyte transformation ability,numbers of CD4 and CD8 subgroups of T lymphocyte in spleen cells were determined.Serum IL-2 concentration and delayed hypersensitivity（DTH）were measured. Results Ginsenosides could increase serum IL-2 concentration and the number of CD4 and CD8 subgroup T lymphocytes,raise the NK killer cell activity and T lymphocyte transformation ability,and increase DTH specific immunologic reaction in the hypoimmunity mice model. Conclusion The Results indicate that ginsenosides can promote immunologic function after γ-ray irradiation and it might be a good reagent for the clinical treatment of hypoimmunity. |
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