| CUI Fengmei,ZHAO Jingyong,LAO Qinhua.Study on HPRT gene mutation of rat peripheral blood lymphocytes induced by internal exposure to radionuclides using cloning method[J].Chinese Journal of Radiological Medicine and Protection,2004,24(6):538-540 |
| Study on HPRT gene mutation of rat peripheral blood lymphocytes induced by internal exposure to radionuclides using cloning method |
| Received:June 17, 2003 |
| DOI： |
| KeyWords:Cloning method Radionuclides Internal exposure Gene mutation Doseresponse relationship |
| FundProject:国防科工委基金资助项目(Y5573062) |
| Author Name | Affiliation | | CUI Fengmei | School of Radiation Medicine and Pulic Health, Suzhou University, Suzhou 215007, China | | ZHAO Jingyong | School of Radiation Medicine and Pulic Health, Suzhou University, Suzhou 215007, China | | LAO Qinhua | School of Radiation Medicine and Pulic Health, Suzhou University, Suzhou 215007, China | | 王六一 | School of Radiation Medicine and Pulic Health, Suzhou University, Suzhou 215007, China | | 杨淑琴 | School of Radiation Medicine and Pulic Health, Suzhou University, Suzhou 215007, China | | 胡明江 | School of Radiation Medicine and Pulic Health, Suzhou University, Suzhou 215007, China |
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| Abstract:: |
| Objective To study HPRT gene mutation in rat peripheral blood lymphocytes induced by internal exposure to radionuclides using cloning method. Methods The radionuclides were injected into the tail vein and HPRT gene mutation was detected using cloning method to study the relationship of dose vs.response and of doserate vs.response. Results The HPRT gene mutation frequecy rose with the increase of accumulative dose and the doserate,both relationships could be described by linearquadratic models. Conclusion Cloning method is relatively sensitive to detect HPRT gene mutation induced by radiation and HPRT gene mutation may be used as a radiobiological dosimeter. |
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