| YOU Han-hu,LIU Xingrong,YANG Zhihua.Effect of intratracheally instilled depleted uranium on immunological function of rats[J].Chinese Journal of Radiological Medicine and Protection,2004,24(6):527-530 |
| Effect of intratracheally instilled depleted uranium on immunological function of rats |
| Received:February 09, 2004 |
| DOI： |
| KeyWords:Depleted uranium (DU) Intratracheal instillation Immunotoxicity |
| FundProject:全军十五指令性课题(L061)国家自然科学基金资助项目(30271524) |
| Author Name | Affiliation | E-mail | | YOU Han-hu | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China | zhumx@nic.ac.cn | | LIU Xingrong | 兰州医学院公共卫生学院 | | | YANG Zhihua | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China | | | 曹珍山 | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China | | | 朱茂祥 | Institute of Radiation Medicine, Academy of Military Medical Science, Beijing 100850, China | |
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| Abstract:: |
| Objective To study immunological effects of depleted uranium in rats. Methods Wistar rats were exposed to depleted uranium by single intratracheal instillation.Body weight and peripheral blood cells were measured weekly and immunological functions were evaluated by weight coefficient of immune organs,plague forming cells of spleenocytes,total and subpopulation counts of lymphocytes in thymus. Results Early after administration,body weight decreased and red blood cells as well as platelets reduced while white blood cells increased,which returned to normal within 1 or 2 months.Immunological functions of spleenocytes and thymocytes were affected dosedependently by depleted uranium. Conclusion Depleted uranium induces immunological dysfunction in rats. |
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