| MIAO Xu-dong,JU Yong-jian,ZHANG Liang-an,et al.Experimental research on effects of fractional irradiation with variable fraction sizes on SMMC7721 liver malignancy cells[J].Chinese Journal of Radiological Medicine and Protection,2004,24(6):523-524 |
| Experimental research on effects of fractional irradiation with variable fraction sizes on SMMC7721 liver malignancy cells |
| Received:October 08, 2003 |
| DOI： |
| KeyWords:Fractional irradiation Cell survival probability MTT Fraction size |
| FundProject:国家自然科学基金资助项目(39670228) |
| Author Name | Affiliation | | MIAO Xu-dong | Department of Radiation Oncology, Nantong No.1 People's Hospital, Jiangsu 226001, China | | JU Yong-jian | Department of Radiation Oncology, Nantong No.1 People's Hospital, Jiangsu 226001, China | | ZHANG Liang-an | 中国医学科学院中国协和医科大学放射医学研究所 | | 王高仁 | Department of Radiation Oncology, Nantong No.1 People's Hospital, Jiangsu 226001, China | | 吴迪军 | Department of Radiation Oncology, Nantong No.1 People's Hospital, Jiangsu 226001, China | | 赵峰 | Department of Radiation Oncology, Nantong No.1 People's Hospital, Jiangsu 226001, China |
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| Abstract:: |
| Objective To analyze the effects of fractional irradiation(FI) with variable fraction sizes(VFS) on SMMC7721 liver malignancy cells. Methods Samples with the same number of SMMC7721 cells were irradiated with different FI protocols,then MTT analysis method was used to determine the cell survival probability after irradiation and comparison was made. Results The S values of the samples irradiated with VFS protocols were all lower than those of the samples irradiated with constant fraction sizes(CFS) protocol,and the differences between part of Results were of statistical significance. And for the same variety range,the effect of FI with decreasing fraction sizes was better than that of FI with increasing ones,also the differences of S values were of statistical significance. Conclusion The result of our experiment using SMMC7721 cells is coincident with the former calculation Results,indicating the VFS irradiation protocols,especially the protocol with decreasing fraction slzes,can be used in the clinic to improve the curative effect. |
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