| CAI Xiao-qing,LI Yu-guo,WU Sheng-wei,et al.Experimental studies of the radioprotective effect of fullerenol in 60Co-γ radiation-injured mice[J].Chinese Journal of Radiological Medicine and Protection,2004,24(6):520-522 |
| Experimental studies of the radioprotective effect of fullerenol in 60Co-γ radiation-injured mice |
| Received:May 08, 2003 |
| DOI： |
| KeyWords:C60 Fullerenol 60Co γ射线 Radioprotection |
| FundProject:国家自然科学基金资助项目(19975066)中国科学院知识创新工程方向性资助项目 |
| Author Name | Affiliation | | CAI Xiao-qing | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China | | LI Yu-guo | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China | | WU Sheng-wei | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China | | 叶波 | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China | | 冉铁成 | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China | | 郭金学 | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China | | 徐慧 | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China | | 李文新 | Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China |
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| Abstract:: |
| Objective To investigate the radioprotective effect of fullerenol. Methods ICR rats were given fullerenol intraperitoneally(i.p.) before and after whole-body 60Co γ-ray irradiation with 5.0 Gy. The change in body weight,index of spleen,index of thymus,peripheral blood counts and SOD activity were observed. Cell cycle of splenoeytes was detected with flow cytometry(FCM). Results Fullerenol showed significant radioprective effect on irradiated mice including increasing the weight of mice,protecting normal immune function of spleen and thymus,curing the decreasing white blood cell and platelet counts. Fullerenol also redused S phase ratio,promoted spleen cell division and proliferation. Conclusion Fullerenol has efficient capacity of radioprotection. The possible mechanism of the radioprotective effect of fullerenol was discussed in this paper. |
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