| ZENG Gui-ying,CHENG Kang,REN Dong-qing.Restorative effect of intestinal RNA on injuries of granulocyte and megakaryocytic series in mice after abdominal γ-irradiation[J].Chinese Journal of Radiological Medicine and Protection,2004,24(6):513-516 |
| Restorative effect of intestinal RNA on injuries of granulocyte and megakaryocytic series in mice after abdominal γ-irradiation |
| Received:December 08, 2003 |
| DOI： |
| KeyWords:Intestinal RNA Mice Granulocyte and megakaryocytic series CFU-GM γ-ray |
| FundProject:国家自然科学基金资助项目(30370440)第四军医大学211工程专项基金资助项目(98X207) |
| Author Name | Affiliation | E-mail | | ZENG Gui-ying | Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China | gyzeng@fmmu.edu.cn | | CHENG Kang | 第四军医大学西京医院心血管内科 | | | REN Dong-qing | Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China | | | 张发科 | Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China | | | 赵涛 | Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China | | | 田芙蓉 | Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China | | | 林海 | Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China | | | 陈永斌 | Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an 710032, China | |
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| Abstract:: |
| Objective To explore the restorative effect of intestinal RNA on injuries of granulocyte and megakaryocytic series in mice after abdominal γ-irradiation. Methods During 1-3 h after abdominal irradiation with 1150 cGy 60Co γ-rays,intestinal RNA was injected into gluteal muscle and regional intestine in mice. The changes of peripheral granulocytes and megakaryocytes cell CFU-GM(colony-forming unit-granulocyte/macrophage) and spleen weight index were measured at different times after irradiation. Results Besides small intestinal injuries there were also granulocyte and megakaryocytic series injuries after abdominal γ-irradiation. The numbers of leucocytes,platelets,CFU-GM and spleen weight index decreased at 6 h,were the most serious on 1 d to 8 d,and began to restore on 15 d after γ-irradiation.The intestinal RNA could increase the number of leucocytes,platelets,CFU-GM and spleen weight index after abdominal γ-irradiation. Single-injection had the same effect as multi-injection. Conclusion Intestional RNA can not only contribute to the restoration of the intestinal injuries but also enhance the restoration of granulocyte and megakaryocytic series injuries in mice after abdominal γ-irradiation. |
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