| WANG Junjie,HUANG Yi,RAN Weiqiang.Clinical application of transperineal 125I-seed implantation guided by ultrasonography in prostate cancer[J].Chinese Journal of Radiological Medicine and Protection,2004,24(6):509-512 |
| Clinical application of transperineal 125I-seed implantation guided by ultrasonography in prostate cancer |
| Received:July 15, 2004 |
| DOI： |
| KeyWords:125I Brachytherapy Prostate carcinmoma Transrectal ultrasonography PSA |
| FundProject: |
| Author Name | Affiliation | | WANG Junjie | The Third Hospital of Beijing University, Beijing 100083, China | | HUANG Yi | 泌尿外科 | | RAN Weiqiang | 超声诊断科 | | 朱丽红 | The Third Hospital of Beijing University, Beijing 100083, China | | 白静 | The Third Hospital of Beijing University, Beijing 100083, China | | 田素青 | The Third Hospital of Beijing University, Beijing 100083, China | | 李金娜 | The Third Hospital of Beijing University, Beijing 100083, China |
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| Abstract:: |
| Objective To establish an optimal technological protocol,and to observe the shortterm efficacy and morbidity of transperineal 125I seed implantation guided by transrectal ulrtrasonography in prostate cancer. Method Thirtytwo patients were treated with transperineal 125I seed brachytherapy guided by transrectal utasound.Among them 6 patientts were treated with the seed implantation plus pre or postexternal beam radiotherapy(EBRT).Biochemical failure was defined as consecutive elevations of PSA level for three times during followup period and the biochemical progressionfree was defined as biochemical control. Results The pre and postimplantation median serum PSA values of 14 patients were (52.14±54.61) ng/ml and (4.26±7.11) ng/ml,respectively (t=3.253,P=0.003).The biochemical control rate was 100%.The pre and posttreatment median PSA values of 12 recurrent prostate cancer patients were (15.14±20.80) ng/ml and (18.94±35.25) ng/ml,respectively (t=-0.307,P=0.764).Their biochemical control rate was 75%.The pre and postimplantation median PSA values of 5 patients with bone metastases were (120.03±145.96) ng/ml and (75.53±84.84) ng/ml,respectively (t=0.527,P=0.621).In 34.62% patients treated only with 125Iseed implication urinary complications were not experience and the incidences of Grade Ⅰ,Ⅱ,Ⅲ,Ⅳ and Ⅴ urinary side effects were 38.46%,11.54%,11.54%,0 and 3.85%,respectively.The incidences of Grade Ⅰ,Ⅱ,Ⅲ and Ⅳ urinary morbidity were 16.67%,0,0 and 16.67%,respectively for patients treated with seed implantation plus EBRT. Grade 1 rectal toxicity was noted in 3.12% patients.In 3.12% patients, one seed migration occurred. Conclusion Transperineal intersitiu permanent brachytherapy is safe,convenient,minimally invasive,with low urinary and rectal side effects. |
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