| LI Xu-dong,LIU Lu,LIU Zhi-yong,et al.Interstitial irradiation using 32P-chromic phosphate during resection of cardio-esophageal carcinoma[J].Chinese Journal of Radiological Medicine and Protection,2004,24(5):435-438 |
| Interstitial irradiation using 32P-chromic phosphate during resection of cardio-esophageal carcinoma |
| Received:January 08, 2004 |
| DOI： |
| KeyWords:Esophageal carcinoma Cardiac carcinoma Lymphatic metastasis Surgical treatment Radiotherapy Colloids Phosphorus radioisotopes |
| FundProject:铁道部科研基金资助项目(J1998Z021);江苏省卫生厅科研基金资助项目(H200117) |
| Author Name | Affiliation | E-mail | | LI Xu-dong | Department of Cardio-thoracic Surgery, South-east University-affiliated Zhongda Hospital, Nanjing 210009, China | luliuzhou@sina.com | | LIU Lu | 210009 南京, 核医学技术研究所 | | | LIU Zhi-yong | Department of Cardio-thoracic Surgery, South-east University-affiliated Zhongda Hospital, Nanjing 210009, China | | | 马超 | 210009 南京, 核医学技术研究所 | | | 王宇 | 210009 南京, 核医学技术研究所 | | | 谢亦山 | 铁道部北京铁路总医院肿瘤外科 | | | 高宏 | 铁道部北京铁路总医院肿瘤外科 | | | 蒋佩明 | Department of Cardio-thoracic Surgery, South-east University-affiliated Zhongda Hospital, Nanjing 210009, China | | | 童冠圣 | 铁道部北京铁路总医院核医学科 | | | 封国生 | 铁道部北京铁路总医院肿瘤外科 | |
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| Abstract:: |
| Objective To explore the effectiveness of 32P-chromic phosphate (32P-colloid) by stromal injection during cardio-esophageal carcinoma resection. Methods To 91 patients with clinically diagnosed cardio-esophageal carcinoma,infiltrative injection of 32P-colloid (296-370 MBq/10 ml) was administer either into the interstitial tissues neighboring to the site of lesion and the region of lymphatic drainage after resection of the tumor or,for those patients whose tumor could not be removed,32P-colloid was injected into the tumor proper and the lymphatic drainage region.The control group included 99 patients with the same diagnosis,who were operated in the same period of time but not injected with 32P-colloid.The peri-operative complication,time and rate of lymphatic metastasis,and the post-operative survival rates at 1-,3-,and 5-year were followed. Results No operative death occurred in both groups.The incidences of peri-operative complication were not different statistically between these two group (P>0.05).The time of lymph node metastasis and the incidences of mediastinal,supraclavicular,and abdominal lymph node metastasis were all statistically different between these two groups (P<0.05).The 1-,3-,and 5-year survival rates were 72.5%,56.4%,and 42.6%,respectively,in the injection group,and were 67.7%,38.1%,and 25.0% in the control group.The 1-year survival rates were not different statistically (P>0.05) between these two groups,while the 3- and 5-year rates were significantly diffeent (P<0.05,P<0.01). Conclusion Stromal medication of 32P-colloid during cardio-esophageal carcinoma resection is a simple and safe procedure in controlling the post-operative lymphatic metastasis and has very fair clinical effectiveness in improving intermediate and late survival rates. |
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