| ZHOU Ying-hui,WU Shi-liang,QIU Hao.Study on changes of collagen and free radicals after electron irradiation in rats[J].Chinese Journal of Radiological Medicine and Protection,2004,24(5):409-411 |
| Study on changes of collagen and free radicals after electron irradiation in rats |
| Received:March 15, 2004 |
| DOI： |
| KeyWords:Electron radiation Radiation injury Collagen expression Free radicals |
| FundProject:国防科工委国防基础科研项目(2003044);江苏省高校自然科学研究基金资助项目(01KJB310001);苏州大学医学发展基金资助项目(2003) |
| Author Name | Affiliation | E-mail | | ZHOU Ying-hui | Suzhou University, Department of Biochemistry and Molecular Biology, Suzhou 215007, China | shiliangwu@hotmail.com | | WU Shi-liang | Suzhou University, Department of Biochemistry and Molecular Biology, Suzhou 215007, China | | | QIU Hao | Suzhou University, Department of Biochemistry and Molecular Biology, Suzhou 215007, China | | | 徐岚 | Suzhou University, Department of Biochemistry and Molecular Biology, Suzhou 215007, China | | | 姜智 | Suzhou University, Department of Biochemistry and Molecular Biology, Suzhou 215007, China | | | 贾伟 | Suzhou University, Department of Biochemistry and Molecular Biology, Suzhou 215007, China | | | 彭淼 | Suzhou University, Department of Biochemistry and Molecular Biology, Suzhou 215007, China | |
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| Abstract:: |
| Objective To investigate the changes of the expression of collagen and free radicals after electron irradiation. Methods An animal model of electron irradiation injury was established using linear accelerator electron radiation.The expression of collagen and the contents of MDA,NOS,SOD,GSH-PX were determind. Results After electron irradiation,the contents of MDA and NOS increased in a certain dosage range,while the contents of SOD,GSH-PX decreased in another dosage range.The expression of collagen was changed.No relationships was showed between the change of collagen and free radicals. Conclusion After electron irradiation,free radicals can be produced in the whole body,but they have little effect on the changes of the collagen expression in irradiated cutaneous tissues.Collagen may play an important role in electron radiation injury. |
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