| JIANG Hao,XIA Yun-fei,LIU Xiu-fang.Survival fraction values at two gray (SF2) in evaluating radiation effect on nasopharyngeal bioptic tumor tissue[J].Chinese Journal of Radiological Medicine and Protection,2004,24(5):403-405 |
| Survival fraction values at two gray (SF2) in evaluating radiation effect on nasopharyngeal bioptic tumor tissue |
| Received:January 15, 2004 |
| DOI： |
| KeyWords:Nasopharyngeal neoplasms Radiotherapy Radiation effect Survival fraction at two gray(SF2) Tumor regression rate |
| FundProject:原中山医科大学211工程建设基金资助项目(98059) |
| Author Name | Affiliation | E-mail | | JIANG Hao | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | xiayunfei@yahoo.com | | XIA Yun-fei | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | | LIU Xiu-fang | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | | 钱剑扬 | Department of Radiation Oncology, Cancer Center, Sun Yat-sen University, Guangzhou 510060, China | | | 梁永钜 | 510060 广州, 中山大学肿瘤防治中心实验研究部 | |
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| Abstract:: |
| Objective To explore the prediction value of radiation effect on survival fraction at two grey(SF2) for bioptic tissue from nasopharyngeal carcinoma. Methods With fresh bioptic specimens from 46 cases of nasopharyngeal carcinoma in Out-patient Department of Tumor Center of Sun Yat-sen University,the survival fraction at 2 gray (SF2) was estimated by the method of image analysis of tissue fragment primary culture.Complete remission doses of nasopharyngeal tumor (CRD-NT),complete remission doses of metastatic cervical lymph nodes (CRD-LN),nasopharyngeal tumor regression rate at 40 gray (NTRR-40),lymph nodal regression rate at 40 Gy (LNRR-40) were assessed by computer tomography scanning and clinical physical examination.The immediate curative effect (ICE) in the patients was evaluated by physical examination and the results of CT scanning at the third month after radiotherapy. Results There were obvious correlations between SF2 and CRD-NT,NTRR-40,CRD-LN,LNRR-40.The partial correlation coefficients were 0.881 (P<0.01),-0.733(P<0.01),0.751((P<)0.01) and -0.609 (P<0.01),respectively.All the 46 cases were grouped by the median of SF2 values.Significant statistical differences of NTRR-40 (P<0.01),CRD-NT(P<0.01),LNRR-40(P<0.01),CRD-NL((P<)0.01) and ICE (P<0.01) were found between the group of SF2 values above the median and the group of SF2 values below the median.Significant statistical difference in CRD-NL (P<0.05) was found in the group of N stage. Conclusion This investigation showed that regression rate has a decreasing trend obviously along with increasing SF2 values.There is a significient correlation between the SF2 value and the immediate curative effect.These results cue that SF2 values could reflect radiation effect on tumor tissue in NPC patients to a certain extent. |
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