| LIU Zhen-fang,SUN Han-ying,LIU Wen-li.Study on the effects of ligustrazine on recovery of hematopoiesis in acute irradiation injured mice[J].Chinese Journal of Radiological Medicine and Protection,2004,24(5):396-398 |
| Study on the effects of ligustrazine on recovery of hematopoiesis in acute irradiation injured mice |
| Received:October 07, 2003 |
| DOI： |
| KeyWords:Ligustrazine Radiation injury VEGF |
| FundProject:国家自然科学基金资助项目(39870926) |
| Author Name | Affiliation | | LIU Zhen-fang | Department of Hematology, Tongji Hospital College, Huazhong University of Science and Technology, Wuhan 430030, China | | SUN Han-ying | Department of Hematology, Tongji Hospital College, Huazhong University of Science and Technology, Wuhan 430030, China | | LIU Wen-li | Department of Hematology, Tongji Hospital College, Huazhong University of Science and Technology, Wuhan 430030, China | | 李春蕊 | Department of Hematology, Tongji Hospital College, Huazhong University of Science and Technology, Wuhan 430030, China | | 谢大兴 | 430030 武汉, 华中科技大学同济医学院附属同济医院分子医学中心 | | 吴宁 | Department of Hematology, Tongji Hospital College, Huazhong University of Science and Technology, Wuhan 430030, China |
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| Abstract:: |
| Objective To explore the effect and possible mechanism of ligustrazine on the recovery of hematopoiesis in acute irradiation-injured mice. Methods The mice were divided into 3 groups:normal group,irradiation-injured group and ligustrazine group.After irradiation by 6.0 Gy 60Coγ-rays,each mouse was given 2 mg ligustrazine orally twice a day for 13 days in the ligustrazine group,and was given equal quantity of saline in the irradiation-injured group.On days 3,7,14 after irradiation,bone marrow mononuclear cells (BMNC) were counted,the percentage of hematopoietic tissue and the expression levels of VEGF and PECAM-1 in bone marrow were evaluated. Results On days 3,7,14 after irradiation,in the ligustrazine group the BMNC counts and the percentage of hematopoietic tissue were higher than those in the irradiation injured group (P<0.01).The PECAM-1 and VEGF expression levels in the ligustrazine group were higher than in the irradiation-injured group on days 3,7 (P<0.01) and lower than in the latter on day 14 (P<0.05). Conclusion Ligustrazine can enhance VEGF and PECAM-1 expression in bone marrow in acute irradiation-injured mice,which may be one of the mechanisms of ligustrazine in accelerating the recovery of hematopoiesis in mouse bone marrow. |
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