LI Hong-xuan,CHEN Hong-hong,CHENG Wen-ying,et al.Study on estimating the dose for 6 MV X-ray partial-body irradiation using contaminated Poisson technique[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):366-369
Study on estimating the dose for 6 MV X-ray partial-body irradiation using contaminated Poisson technique
Received:October 08, 2003  
DOI:
KeyWords:Chromosome aberration  Simulated partial-body irradiation  Radiotherapy  Contaminated Poisson method  X-rays
FundProject:复旦“985”基金资助项目
Author NameAffiliation
LI Hong-xuan Institute of Radiation Medicine, Fudan University, Shanghai 200032, China 
CHEN Hong-hong Institute of Radiation Medicine, Fudan University, Shanghai 200032, China 
CHENG Wen-ying Institute of Radiation Medicine, Fudan University, Shanghai 200032, China 
邹美君 Institute of Radiation Medicine, Fudan University, Shanghai 200032, China 
徐萍 Institute of Radiation Medicine, Fudan University, Shanghai 200032, China 
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Abstract::
      Objective To explored the applicability of estimation of the dose and irradiated fraction using the contaminated Poisson method in partial-body simulated exposures and medical exposures with 6 MV X-rays. Methods Partial-body accidental irradiations were simulated by in vitro irradiation of blood from healthy volunteers. The dicentric plus ring aberrations were analyzed by simulated 20%, 50%, 80% exposure to 2, 4 Gy of 6 MV X-rays. Three cancer patients treated with radiotherapy were included in the study. Blood samples of the patients were obtained 24 h before and after treatment. Lymphocytes were cultured in the usual way and metaphases were scored for dicentric and centric ring aberrations. The dose and fraction of cells irradiated were estimated by the contaminated Poisson method. Results The lymphocytes of 80% exposure to 2 Gy and 20%, 50%, 80% exposure to 4 Gy showed an overdispersed distribution of dicentrics plus rings, and their estimates of irradiation dose and irradiated fraction fell within 30% of the true values in simulated partial-body irradiation. The 2 Gy radiotherapy in the pelvic region and the fraction of irradiated red bone marrow being larger than 20% or radiotherapy in the skull region involving large dose (3 Gy) of 6 MV X-rays produced an overdispersed distribution of dicentrics plus rings. The estimates of irradiated fraction were consistent with those of the fraction of irradiated red bone marrow of the red marrow of whole body. At the higher dose of radiotherapy (3 Gy), the dose estimate, which was 23% off, was a good accuracy to attain. It is noted that the results in vivo were in good agreement with those of simulated partial-body irradiation from cancer patients. Conclusion Contaminated Poisson method will be feasible in the assessment of dose and fraction in accidents involving larger dose partial-body exposure.
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