| JIANG De-fu,CHENG Guang-hui,MA Ying-zhe.Relationship between prognosis of breast cancer and expressions of C-erbB-2,PCNA,Bcl-2,P53 and nm23-H1 protein[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):358-360 |
| Relationship between prognosis of breast cancer and expressions of C-erbB-2,PCNA,Bcl-2,P53 and nm23-H1 protein |
| Received:January 08, 2004 |
| DOI： |
| KeyWords:Breast cancer Immunohistochemistry Prognostic factors |
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| Abstract:: |
| Objective To examine the expressions of C-erbB-2, PCNA, Bcl-2, P53 and nm23-H1 protein after modified radical mastectomy, and evaluate the relationship between their expressions and prognosis. Methods A total of 61 cases with breast cancer received the same treatment and their postoperative paraffin-embedded specimens were used for immunohistochemical study to examine the expressions of ER, PR, C-erbB-2, PCNA, Bcl-2, P53, nm23-H1 protein. The 5, 8-year survival rates were observed by fllow-up. Results The 5 and 8 year survival rates were statisticly different between the patients with different tumor size, histological grading, number of cancer metastasized lymph nodes ( P <0.05).They were also statisticlly different between the patients with positive and negative expressions of ER, PR, C-erbB-2, and Bcl-2, PCNA, P53 and nm23-H1 protein(P <0.05), but they were negatively correlated with patients'age. Conclusion C-erbB-2, Bcl-2, PCNA, p53 and nm23-H1 gene can all become the independent prognostic factors of breast cancer. |
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