| NIE Chang-fu,GUO Zhi-hua,WANG Jian-guo,et al.Evaluating the effect of transcatheter arterial chemoembolization on AFP mRNA in peripheral blood of hepatocellular carcinoma patients[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):356-358 |
| Evaluating the effect of transcatheter arterial chemoembolization on AFP mRNA in peripheral blood of hepatocellular carcinoma patients |
| Received:January 12, 2004 |
| DOI： |
| KeyWords:Transcatheter arterial chemoembolization Liver neoplasm AFP mRNA Real time RT-PCR |
| FundProject:河南省教育厅自然科学基金资助项目(20003320146) |
| Author Name | Affiliation | | NIE Chang-fu | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | GUO Zhi-hua | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | WANG Jian-guo | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 荆晓岳 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 李荣 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 孔凡明 | The First Affiliated Hospital of Xinxiang Medical College, Weihui 453100, China | | 何蕴韶 | |
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| Abstract:: |
| Objective To evaluate the effect of transcatheter arterial chemoembolization (TACE)on AFP mRNA in peripheral blood of patients with hepatocellular carcinoma(HCC). Methods Real time RT-PCR was used to detect AFP mRNA expression in peripheral blood of 24 patients with HCC before and after TACE. Results The expression level of AFP mRNA in peripheral blood of the 24 HCC patients averaged (133 074.6± 27 163.7) copies/μgRNA before TACE treatment and(2076.0±423.8)copies/μgRNA, (1774.5±362.2)copies/μgRNA; (23 650.4± 4827.6)copies/μgRNA at 24 hours, 1 month and 2 months after TACE. Conclusion The expression of AFP mRNA is significantly reduced after TACE and it can be used as a marker for evaluating the treatment efficacy for hepatocellular carcinoma. |
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