| QU Shuang,CHEN Ying,GE Shi-li,et al.Study of chromosome translocation in victims of a previous radiation accident by atomic force microscopy[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):353-356 |
| Study of chromosome translocation in victims of a previous radiation accident by atomic force microscopy |
| Received:January 06, 2004 |
| DOI： |
| KeyWords:Atomic force microscopy Radiation Chromosome aberration Translocation Hot damage point |
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| Abstract:: |
| Objective To explore the potentiality of atomic force microscopy in analysis of chromosome aberration, observation of chromosome structure, and study the mechanisms of radiation damage and cancer development. Methods G-banding method was used to localize break point on translocation of chromosomes from five survivors at the 12th year after Shanghai radiation accident. The frequency of chromosome aberrations was analyzed by AFM and compared with the results observed by optical microscopy. Results AFM could not only identify the exact sites of break-point, but also display the three-dimensional structures of hot damage points by high resolving power. Conclusion AFM can provide more information for study of chromosome aberration induced by radiation, including visualizing the structures of hot damage points, as a basis of further research in genomic level. |
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