| CHEN Ying,GE Shi-li,LUO Yi-sheng,et al.A follow-up study of chromosome aberrations 12 years after exposure to a radiation accident in Shanghai[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):350-352 |
| A follow-up study of chromosome aberrations 12 years after exposure to a radiation accident in Shanghai |
| Received:November 25, 2003 |
| DOI： |
| KeyWords:Chromosome aberrations Translocations Late effects of radiation |
| FundProject: |
| Author Name | Affiliation | | CHEN Ying | Beijing Institute of Radiation Medicine, Beijing 100850, China | | GE Shi-li | Beijing Institute of Radiation Medicine, Beijing 100850, China | | LUO Yi-sheng | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 刘秀林 | Beijing Institute of Radiation Medicine, Beijing 100850, China | | 金璀珍 | Beijing Institute of Radiation Medicine, Beijing 100850, China |
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| Abstract:: |
| Objective A follow-up study of chromosome aberrations in 5 victims accidentally exposed to 60 Co-γ-rays 12 years ago was performed to give assessments of the late effect of radiation. Methods Conventional chromosome aberration, G-banding automatic karyotype analysis and WCP 1 FISH technique were used simultaneously. Results Unstable aberrations had been almost lost. Stable aberrations such as reciprocal translocations were observed predominately. The results of karyotype analysis and FISH were very approximate and contributed to the dose-response relationship. Conclusion Stable aberrations are fairly proper for assessment of the late effect of radiation although age and time factors should be considered. |
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