| HUANG Pei-lin,TONG Guan-sheng,LIU Lu,et al.An experimental study on effect of 32P colloid on lymphatic metastasis of transplanted H22 hepatoma in mices[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):324-327 |
| An experimental study on effect of 32P colloid on lymphatic metastasis of transplanted H22 hepatoma in mices |
| Received:January 08, 2004 |
| DOI： |
| KeyWords:Chromic 32P phosphate colloid Mouse Ascitic hepatoma Lymph metastasis Biodistribution |
| FundProject:江苏省社会发展基金资助项目(BS2000062);铁道部医学科研基金资助项目 |
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| Abstract:: |
| Objective To study the anticancer effects and biodistribution of chromic 32 P phosphate colloid in mice with lymphatic metastasis of hepatoma after intratumoral injection. Methods Forty-eight Km mice with H22 ascites hepatoma were injected with 32 P colloid intratumorally.The distribution of 32 P in regional lymph nodes and other organs was observed dynamically, and its anticancer effectiveness was investigated in the tumor and regional lymph nodes. Results 32 P mainly remained in the tumor and regional lymph nodes, while the of 32 P organs, such as liver, spleen, lung, only retained a mild activity. By histopathologic observation, neoplamic focis could be found in pad, right popliteal lymph node and groin lymph node, and necrosis was seen in the tumor and its metastatic foci in right popliteal lymph node. On day 17 after 32 P treatment, the transplanted tumor focis necrosed thoroughly, and normal structure of regional lymph nodes disappeared, which was replaced by necrotic tissue and hemorrhage. Conclusion The intratumoral administration of chromic [ 32 P] colloid could be used for treatment of the primary tumor, and lymphatic metastatic focus as well, in order to produce obvious anticancer effects. |
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