| YE Jiang-feng,QI Hao-wen,FAN Feng-yun,et al.Pathomorphologic observation on treatment of radiation-induced lung damage in rats with fluvastatin[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):321-324 |
| Pathomorphologic observation on treatment of radiation-induced lung damage in rats with fluvastatin |
| Received:January 08, 2004 |
| DOI： |
| KeyWords:Radiation-induced lung injury Fluvastatin Pathomorphology |
| FundProject:第四军医大学西京医院高新技术项目(200120) |
| Author Name | Affiliation | | YE Jiang-feng | Department of Respirator Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710033, China | | QI Hao-wen | Department of Respirator Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710033, China | | FAN Feng-yun | | | 蒙育林 | | | 赵峰 | Department of Respirator Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an 710033, China | | 石梅 | | | 赵一岭 | |
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| Abstract:: |
| Objective To inquire into the means of preventing lung damage induced by thoracic irradiation. Methods SD rats were divided randomly into 3 groups: normal control, irradiated control (Group IC) and irradiated and fluvastatin (Flu)-treated group (Group F). The later two groups of rats were irradiated with X-rays at a dose of 20 Gy thoracically. Beginning from the seventh day before irradiation the rats in the Group F were treated with Flu at a dose of 20 mg per day by garaging until the end of the experiment. Animals from each group were sacrificed on days 5, 15, 30, 60 respectively after irradiation. Sections of lung were examined with light microscopy, electron microscopy and morphometry. Results The rats in the Group IC suffered from typical radiation pneumonitis (P <0.01). Electron microscopy indicated type Ⅱpneumonocytes and capillary endothelial cells were injured in rats of Group IC on days 30, 60. There were increase of collagen and a great quantity of mast cells in irradiated control rats. In rats of the Group F there was slight reaction in the lung. Conclusion Fluvastatin could reduce radiation pneumonitis and inhibit increase of collagen. The treatment and prevention of radiation-induced lung injury in rats with fluvastatin is effective. |
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