JU Gui-zhi,FU Shi-bo,YAN Feng-qin.Experimental study on cell cycle uncoupling induced by ionizing radiation[J].Chinese Journal of Radiological Medicine and Protection,2004,24(4):295-296
Experimental study on cell cycle uncoupling induced by ionizing radiation
Received:November 05, 2003  
DOI：
KeyWords:Ionizing radiation  Cell cycle uncoupling
FundProject:国家自然科学基金资助项目(30270346)
Author NameAffiliation
JU Gui-zhi MH of Radiobiology Research Unit, Medical Center in Memorial of Norman Bethune of Jilin University, Changchun 130021, China 
FU Shi-bo MH of Radiobiology Research Unit, Medical Center in Memorial of Norman Bethune of Jilin University, Changchun 130021, China 
YAN Feng-qin MH of Radiobiology Research Unit, Medical Center in Memorial of Norman Bethune of Jilin University, Changchun 130021, China 
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Abstract::
      Objective To investigate whether or not cell cycle uncoupling could be induced by ionizing radiation. Methods Cell cycle was analyzed by flow cytometry (FCM) following staining of cells with propidium iodide (PI) and polyploid cells were analyzed. Results It was found that 24 h after exposure of SKOV-3 cells to X-rays at the doses of 1.0, 2.0, 4.0 or 6.0 Gy, the 2 N cells were decreased significantly (P <0.01 respectively), whereas both 4 N and 8 N cells were increased significantly ( P <0.01 for all cases). Conclusion Cell cycle uncoupling could be induced by ionizing radiation.
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