| QIANG Yong-gang,LIAO Yong-hua.Effects of restrain and regulation on production of β-adrenergic receptors in lung of Sprague-Dawley rats by 60Co γ-ray irradiation[J].Chinese Journal of Radiological Medicine and Protection,2004,24(3):237-239 |
| Effects of restrain and regulation on production of β-adrenergic receptors in lung of Sprague-Dawley rats by 60Co γ-ray irradiation |
| Received:May 14, 2003 |
| DOI： |
| KeyWords:γ-ray irradiation Receptor production Restrain and regulation |
| FundProject:广东省医药卫生科研基金资助项目(A2001482) |
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| Abstract:: |
| Objective To study the restrain and regulation on production of β-adrenergic receptors in Sprague-Dawley rat lung by 20 Gy γ-ray irradiation. Methods To determine production of β-adrenergic receptors(Bmax ) after irradiation and BAAM irreversible blockade by radioligand binding assay of receptors. Results β-adrenergic receptors were sensitive to γ-rays,and the sensitivity level declined to the lowest on day 20 after radiation,then the receptors were recovered gradually.But the receptor production rate(Pr) was slower,i.e.,Pr was (0.36±0.03)×109 sitesmg proteinh [control groups,(8.20±1.47)×109].The half-time of update(T1/2 )was put off for 10.9 days as compared to BAAM group. Conclusion Production of receptors can be restrained by 20 Gy γ-ray irradiation,resulting in lower receptor production rate,and longer half-time of update(T1/2 ). |
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