| PU Xiao-yun,CHEN Xiao-li,PAN Jing.The affect of bone marrow cell biomechanical characteristics to 6 Gy γ irradiation-injured mice[J].Chinese Journal of Radiological Medicine and Protection,2004,24(3):231-233 |
| The affect of bone marrow cell biomechanical characteristics to 6 Gy γ irradiation-injured mice |
| Received:January 18, 2003 |
| DOI： |
| KeyWords:Biomechanical characteristics Bone marrow cells Adhesiveness Surface charge Deformability |
| FundProject:全军“九五”攻关课题基金资助项目 |
| Author Name | Affiliation | | PU Xiao-yun | Hemotologic department, Faculty of medical laboratory Technology, Third Military Medical University, Chongqing 400038, China | | CHEN Xiao-li | Hemotologic department, Faculty of medical laboratory Technology, Third Military Medical University, Chongqing 400038, China | | PAN Jing | Hemotologic department, Faculty of medical laboratory Technology, Third Military Medical University, Chongqing 400038, China | | 李招权 | Hemotologic department, Faculty of medical laboratory Technology, Third Military Medical University, Chongqing 400038, China | | 邓均 | Hemotologic department, Faculty of medical laboratory Technology, Third Military Medical University, Chongqing 400038, China | | 黄辉 | Hemotologic department, Faculty of medical laboratory Technology, Third Military Medical University, Chongqing 400038, China | | 叶勇 | Hemotologic department, Faculty of medical laboratory Technology, Third Military Medical University, Chongqing 400038, China |
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| Abstract:: |
| Objective To explore the change of bone marrow cell biomechanical characteristics in radiation-injured mice and the influencing factors. Methods Male Kumming mice were exposed to total body irradiation of 6 Gy γ-rays from a 60Co source.Electrophoresis,DPH probe,micropore filter,and adhesion rate methods were used to detect cell surface charge,membrane microviscosity,cell deformability,and cell adhesion,respectively. Results The deformability,adhesiveness and cell surface charges of bone marrow cells(including hematopoietic cells and stromal cells)were dramatically decreased,but membrane microviscosity was obviously increased after irradiation on 1 d,3 d and 7 d. Conclusion The biomechanical characteristics of bone marrow cells are obviously changed after radiation injury.It might be one of the reasons of hematopoietic failure after irradiation. |
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