| ZHANG Wei,WANG Chun-yan,Hayata Isamu .Cytogenetic study of stable chromosome aberrations in residents of a high background radiation area in China[J].Chinese Journal of Radiological Medicine and Protection,2004,24(3):228-230 |
| Cytogenetic study of stable chromosome aberrations in residents of a high background radiation area in China |
| Received:March 03, 2004 |
| DOI： |
| KeyWords:High background radiation Chromosomal translocation Lymphocytes Fluorescence in situ hybridization Environmental mutagen |
| FundProject:日本京都体质研究会资助项目(卫国合双字95第0308号) |
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| Abstract:: |
| Objective To investigate the effect of high background radiation on the induction of stable chromosome aberrations. Methods By fluorescence in situ hybridization(FISH) technique chromosome Nos.1,2 and 4 were painted using specific biotin-labeled whole chromosome painting probes.Peripheral blood specimens were taken from 31 individuals living in the high background radiation area(HRBA) and 29 individuals in the control area. Results No significant difference was found in the frequencies of translocations between HBRA and the control (P>0.05,Mann-Whitney U test) for both children and elderly individuals.On the other hand,correlation between age and translocation frequencies was significant at the 1% level(rs =0.388 with 56DF). Conclusion There are no differences in the frequencies of translocations between HBRA and the control area.The present result indicates that the contribution of an elevated level of natural radiation in HBRA in China to the induction rate of stable type aberrations(translocations)dose not have a significant effect compared with the contributions from all other sources such as chemical mutagens and(or) metabolic factors. |
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