| WU Ning,SUN Han-ying,LIU Wen-li.Expression of bFGF,VEGF in bone marrow of mice with radiation injury[J].Chinese Journal of Radiological Medicine and Protection,2004,24(3):210-221 |
| Expression of bFGF,VEGF in bone marrow of mice with radiation injury |
| Received:July 28, 2003 |
| DOI： |
| KeyWords:Irradiation Bone marrow bFGF VEGF |
| FundProject:国家自然科学基金资助项目(39870926) |
| Author Name | Affiliation | | WU Ning | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China | | SUN Han-ying | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China | | LIU Wen-li | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China | | 孟凡凯 | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China | | 李春蕊 | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China | | 余源 | Department of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 430030, Wuhan, China |
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| Abstract:: |
| Objective To analyze the expression of bFGF,VEGF in mice bone marrow after exposure to γ-radiation. Methods Kunming strain mice irradiated with 6.0 Gy 60Co γ-rays were used to analyze the bFGF and VEGF expression in bone marrow on days 3,7,14 after irradiation by immunohistochemistry. Results Expressions of bFGF,VEGF in bone marrow of the irradiation group were significantly lower than those of the normal group( P <0.01),and were still lower 14 days after irradiation( P<0.05 or P <0.01).But the expressions of bFGF and VEGF in bone marrow showed a direct correlation( r =0.824, P <0.01). Conclusion γ-radiation inhibits bFGF,VEGF expressions in bone marrow,suggesting that the abnormal expressions were ralated to the injury of hematopoietic microenvironment(HIM)cause by γ-radiation. |
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