| TAO Zu-fan,SUN Quan-fu,ZOU Jian-ming,et al.Study of cancer mortality among inhabitants in the high background radiation area of Yangjiang, China (1979-1998)[J].Chinese Journal of Radiological Medicine and Protection,2004,24(2):143-148 |
| Study of cancer mortality among inhabitants in the high background radiation area of Yangjiang, China (1979-1998) |
| Received:September 11, 2003 |
| DOI： |
| KeyWords:High background radiation area Cancer mortality Relative risk |
| FundProject:日本体质研究会基金资助 |
| Author Name | Affiliation | | TAO Zu-fan | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | SUN Quan-fu | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | ZOU Jian-ming | 广东省职业病防治院, | | 查永如 | 广东省职业病防治院, | | 李嘉 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 刘玉升 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China | | 袁镛龄 | 湖南省劳动卫生研究所, | | 秋俶澄伯 | 日本鹿儿岛大学, | | 菅原努 | 日本体质研究会 | | 魏履新 | National Institute for Radiological Protection, Chinese Center for Disease Control and Prevention, Beijing 100088, China |
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| Abstract:: |
| Objective The objective of the study is to explore cancer risk associated with the low-level radiation exposure of average annual effective dose of 6. 4 mSv occurring in the high background radiation area(HBRA) in Yangjiang of Guangdong Province, China. Methods The data of cancer mortality for period of 1979-1986 were collected in prospective follow-up survey of dynamic populations and those of 1987-1998 were obtained from a fixed cohort in the same method. Record linkage was used to combine the two data sets. The external dose received by the inhabitants was estimated on the basis of hamlet-specific environmental doses and sex-age-specific occupancy factors, and the fixed values of internal dose regardless of sex and age was assumed. Relative risk (RR) and excess relative risk coefficient (ERR/Sv) and their 95% confidence interval (CI) were calculated using the AMFIT in Epicure. Results During the period of 1979-1998, the follow-up for 125 079 subjects accumulated 1 992 940 person-years and identified 12 444 deaths, including 1202 cancer deaths. The RR of mortality of all cancers in whole HBRA was 1. 00 (95% CI, 0. 89-1. 14) showing no statistical difference between the HBRA and the control area (CA). The RRs of all cancers in low, intermediate and high dose groups in the HBRA did not show statistical difference from the control group, either. The region (Yangdong and Yangxi) and the follow-up period(1979-1986 and 1987-1998) did not evidently modify the results, and the restriction of cancer cases to those with pathology information made no statistically significant change in RRs. In site-specific cancer analysis, only the RR of esophageal cancer showed statistical excess in the HBRA, the others did not show statistical difference between the HBRA and the CA. The comparison of RRs of site-specific cancer mortality among different dose groups and the dose-response analysis of site-specific cancer mortality related to cumulative individual lifetime dose did not give any monotonic trend, the P-values were larger than 0. 05 for all, including esophageal cancer. Interestingly to note that, the mortality of liver cancer, which is virus-related and the most common cancer in the studied areas, showed a statistical decrease among the HBRA inhabitants with the dose range of 400 mSv or higher compared to those of 0-199 mSv, RR=0. 31 (95%CI, 0. 13-0. 66). The ERR/Sv for all solid cancers associated with cumulative individual lifetime dose was estimated to be -0. 06 (95%CI, -0. 60-0. 67). Conclusions The mortality of all cancers showed no statistical difference between the HBRA and the CA;any radiation-related excess of site-specific cancer in HBRA could not be found. |
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