| JU Yong-jian,CHEN Mei-hua,SUN Fu-yin.Comparison between evaluating methods about the protocols of different dose distributions in radiotherapy[J].Chinese Journal of Radiological Medicine and Protection,2004,24(2):133-135 |
| Comparison between evaluating methods about the protocols of different dose distributions in radiotherapy |
| Received:January 18, 2003 |
| DOI： |
| KeyWords:Tumor control probability Equivalent uniform dose Radiotherapy Dose |
| FundProject:国家自然科学基金资助项目(39670228) |
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| Abstract:: |
| Objective To study the relationship between tumor control probability (TCP) or equivalent uniform dose (EUD) and the heterogeneity degree of the dose changes with variable biological parameter values of the tumor. Methods According to the definitions of TCP and EUD, calculating equations were derived. The dose distributions in the tumor were assumed to be Gaussian ones. The volume of the tumor was divided into several voxels, and the absorbed doses of these voxels were simulated by Monte Carlo methods. Then with the different values of radiosensitivity (α) and potential doubling time of the clonogens (Tp), the relationships between TCP or EUD and the standard deviation of dose (Sd) were evaluated. Results The TCP-Sd curves were influenced by the variable α and Tp values, but the EUD-Sdcurves showed little variation. Conclusion When the radiotherapy protocols with different dose distributions are compared, if the biological parameter values of the tumor have been known exactly, it's better to use the TCP, otherwise the EUD will be preferred. |
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