| ZHU Fei-peng,WANG Hong-fu,GAO Lin-feng.Effect of alpha-calciferol on bone metabolism in rats with radiation injury to kidney[J].Chinese Journal of Radiological Medicine and Protection,2004,24(2):125-127 |
| Effect of alpha-calciferol on bone metabolism in rats with radiation injury to kidney |
| Received:May 16, 2003 |
| DOI： |
| KeyWords:Radiation Kidney Bone metabolism Alpha-calciferol |
| FundProject: |
| Author Name | Affiliation | | ZHU Fei-peng | Laboratory of Bone, Metabolism, Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | WANG Hong-fu | Laboratory of Bone, Metabolism, Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | GAO Lin-feng | Laboratory of Bone, Metabolism, Institute of Radiation Medicine, Fudan University, Shanghai 200032, China |
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| Abstract:: |
| Objective To study the protective effect of alpha-calciferol on bone metabolism in rats with radiation injury to kidney. Methods Six-month-old male SD rats were randomly divided into three groups:model group, sham group, and alpha-calciferol (Bone-One) group, 10 rats each. The model group was developed by irradiation of rat kidneys with 15 Gy of Cs 137 γ-rays. One week after radiation, alpha-calciferol group was given orally Bone-One, 0. 1 μg·kgBW -1·d-1, suspended in 1% CMC, 1 ml a rat for 90 days. BMD of L 1-4, bone histomorphometry, bone biomechanical properties were measured in all rats at the end of experiment. Results BMD of L1-4 was significantly lowered, volume and thickness of trabecular bone were significantly decreased, space of trabecular bone increased, ineral apposition rate (MAR), maximal load of femur and lumbar vertebra decreased (P<0. 05, P <0. 01) in model group, compared with sham group. In alpha-calciferol group, BMD of L1-4, volume and thickness of trabecular bone increased, space of trabecular bone decreased significantly (P <0. 05, P <0. 01), MAR, maximal load of femur and lumbar vertebra increased significantly ( P <0. 05, P <0.01), compared with model group. Conclusion Alpha-calciferol improves disturbance of bone metabolism in rats with radiation injury to kidney. |
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