| LI Rong,SU Yong-ping,GUO Yong.Distribution of uranium in rats with implanted and removed depleted uranium fragments[J].Chinese Journal of Radiological Medicine and Protection,2004,24(2):105-107 |
| Distribution of uranium in rats with implanted and removed depleted uranium fragments |
| Received:January 20, 2003 |
| DOI： |
| KeyWords:Depleted uranium Distribution Kinetics Implanted fragments |
| FundProject:全军“十五”指令性课题(01L061) |
| Author Name | Affiliation | | LI Rong | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China | | SU Yong-ping | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China | | GUO Yong | 北京放射医学研究所 | | 徐辉 | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China | | 楼淑芬 | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China | | 艾国平 | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China | | 于水 | 北京放射医学研究所 | | 黄跃生 | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China | | 蒋建新 | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China | | 郑怀恩 | Institute of Combined Injuries, Statt key Laboratory of Trauma, Burn and Combined Injury, Third Military Medical College, Chongqing 400038, China |
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| Abstract:: |
| Objective To determine the distribution of uranium in rats with fragments of depleted uranium (DU) implanted in muscle and the residual influence of removed uranium fragments. Methods Rats were surgically implanted with sterilized DU within muscle under anesthesia. At 5 days after implantation, the fragments were removed from rats in several groups while they were not removed in the other groups. At 1, 3, 7, 15, 20, and 26 days after implantation, tissue samples were collected from all animals. Using a lazer phosphorescence analyzer, uranium levels were measured. Results At all time points, uranium concentrations in all samples in the implanted rats were significantly greater than those in the control group, especially in kidney, ovary and sternum. Uranium concentrations in most samples in the implanted rats were greater than in the rats with removed fragments. Conclusion Kidney, ovary and sternum are the primary organs for uranium redistributed from intramuscularly embedded DU fragments. Removing DU fragments and excising the surrounding muscles would reduce the uranium concentrations in tissues in the implanted rats. |
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