| QIU Hao,WU Shi-liang,XU Lan,et al.Changes of collagen metabolism induced by 60Co γ-ray external irradiation[J].Chinese Journal of Radiological Medicine and Protection,2004,24(2):102-104 |
| Changes of collagen metabolism induced by 60Co γ-ray external irradiation |
| Received:September 08, 2003 |
| DOI： |
| KeyWords:γ-rays Radiation injury Collagen metabolism |
| FundProject:国防科工委国防预研基金资助项目(Y692002604);江苏省高校自然科学研究基金资助项目(01KJB310001) |
| Author Name | Affiliation | E-mail | | QIU Hao | Department of Biochemistry and Molecular Biology, Suzhou University Medical College, Suzhou 215007, China | shiliangwu@hotmail.com | | WU Shi-liang | Department of Biochemistry and Molecular Biology, Suzhou University Medical College, Suzhou 215007, China | | | XU Lan | Department of Biochemistry and Molecular Biology, Suzhou University Medical College, Suzhou 215007, China | | | 周迎会 | Department of Biochemistry and Molecular Biology, Suzhou University Medical College, Suzhou 215007, China | | | 史宁 | Department of Biochemistry and Molecular Biology, Suzhou University Medical College, Suzhou 215007, China | | | 彭淼 | Department of Biochemistry and Molecular Biology, Suzhou University Medical College, Suzhou 215007, China | |
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| Abstract:: |
| Objective To study the changes and molecular mechanism of collagen metabolism induced by 60Co γ-ray external irradiation of local tissues. Methods After the hip skin of rabbits was irradiated with 60Co γ-rays, the changes of collagen metabolism and collagen contents of the rabbits' skin of different sex groups were determined. Results The γ-rays decreased the soluble collagen contents (especially type Ⅲ) and increased the activity of MMPs in local tissues. Although the radiation affected the contents of serum SOD, 5-HT, and LPO, its influence on the contents in local tissues was not remarkable. There were changes of collagen metabolism in local tissues after radition injury, but no differences were found in SOD, 5-HT, LPO, and glycosamine of tissues. Conclusion The main mechanism of skin burn induced by 60Coγ-rays may be that the changes of collagen metabolism bring about the pathological effect. |
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