| LÜ Qiu-jun,WEN Li-qing,ZHANG Min.Study on radiation protective effect of resveratrol and its molecular mechanism[J].Chinese Journal of Radiological Medicine and Protection,2004,24(1):21-22 |
| Study on radiation protective effect of resveratrol and its molecular mechanism |
| Received:March 18, 2003 |
| DOI： |
| KeyWords:Resveratrol Radiation Mouse Apoptosis |
| FundProject:总后“十五”指令性基金资助项目(01L022) |
| Author Name | Affiliation | | LÜ Qiu-jun | Institute of Radiation Medicine.Academy of Military Medical Sciences, Beijing 100850, China | | WEN Li-qing | Institute of Radiation Medicine.Academy of Military Medical Sciences, Beijing 100850, China | | ZHANG Min | Institute of Radiation Medicine.Academy of Military Medical Sciences, Beijing 100850, China | | 郭绍明 | Institute of Radiation Medicine.Academy of Military Medical Sciences, Beijing 100850, China | | 陈媛媛 | Institute of Radiation Medicine.Academy of Military Medical Sciences, Beijing 100850, China | | 吴祖泽 | Institute of Radiation Medicine.Academy of Military Medical Sciences, Beijing 100850, China |
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| Abstract:: |
| Objective To investigate radiation-protective effect of resveratrol and its molecular mechanism. Methods Kunming mice were ig administered with resveratrol before 60Coγ-irradiation.Thirty-day survival rate and the average life span of dead mice post-irradiation were observed.The apoptosis of spleen from irradiatied mice was detected by FACS and in situ termianl labeling method.The effect of resveratrol on the activities of Caspase-3 and Caspase-8,and the expression levels of Bcl-2 and Fas were examined. Results Administration with resveratrol resulted in increases of 30-day survival rate and prolongation of average life span of the dead mice.Aoptotic rate of spleen cells decreased,expression level of bcl-2 increased,the expression of Fas did not change,and the activities of Caspase-3 and Caspase-8 increased in spleen cells of irradiation groups. Conclusion The results indicate that resveratrol has radiation-protective effect and its mechanism might be related with its suppression of apoptosis of radiation-sensitive cells. |
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