| CHEN Honghong,HU Yuxing,WANG Yinghua.Protective effects of chelating agents of catechols amino carboxylic acid type on radiation injury induced by radiothorium in mice Ⅱ.delayed administration[J].Chinese Journal of Radiological Medicine and Protection,2003,23(6):426-430 |
| Protective effects of chelating agents of catechols amino carboxylic acid type on radiation injury induced by radiothorium in mice Ⅱ.delayed administration |
| Received:November 11, 2002 |
| DOI： |
| KeyWords:Chelating agent Thorium-234 Internal radiation injury Lipid peroxidation Decorporation |
| FundProject:国家自然科学基金青年基金资助项目(39700039) |
| Author Name | Affiliation | | CHEN Honghong | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | HU Yuxing | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | WANG Yinghua | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 金美英 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 罗梅初 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China | | 孙梅贞 | Institute of Radiation Medicine, Fudan University, Shanghai 200032, China |
|
| Hits: 2617 |
| Download times: 1678 |
| Abstract:: |
| Objective To explore antioxidation efficacy of chelating agents (9501,7601) of catechols a m ino carboxylic acid type for radiothorium in vivo and relationship between t heir antioxidation and decorporation effects.To verify whether 9501 and 7601 could improve the protective effects for internal radiation injury. Methods The chelating agents were administered intramuscularly to ICR mice 3 days after intraperitoneal injection of 0 6 MBq 234Th-citrate for three consecutive days and the animals were sacrificed eight days late r.The 234Th radioactivity in the whole body and its retention in the l iver and skeleton were determined.The malondialdehyde (MDA) production as an ind ex of 234Th-induced lipid peroxidation in bone marrow and liver was a ssayed and the numbers of bone marrow nucleated cells (NBMNC) were counted.The p athological changes of bone marrow and liver tissue were observed. Results When 9501 and 7601 and DTPA were postponed to administer to 234Th-inc orpo rated mice,the whole body radioactivity was only decreased by 15%-16% and the r etention of 234Th in the liver, and skeleton was reduced to 77%-79% a n d 72%-75% as compared with the control group,respectively.They showed the simil ar removal effectiveness which was significantly lower than that when administed promptly.However,9501 and 7601 could inhibit 234Th-induced lipid peroxid ation,causing significant reduction of MDA content in bone marrow and liver, and markedly ameliorate histopathological changes of bone marrow and liver tissue in 234Th-treated mice.DTPA appeared to have a lower effectiveness.VitE hadn’t decorporation activity and slightly alleviated internal radiation injury. Conclusion The chelating agents 9501 and 7601 of catechols amino c arboxylic acid type have double functions of more effective decorporation and an tioxidation and can improve the curative effects.They are worth further investig ation. |
| HTML View Full Text View/Add Comment Download reader |
| Close |
|
|
|
