| TANG Yi,LIU Wenli,ZHOU Jianfeng.Change of cell cycle arrest of tumor cell lines after 60Coγ-irradia tion[J].Chinese Journal of Radiological Medicine and Protection,2003,23(6):418-420 |
| Change of cell cycle arrest of tumor cell lines after 60Coγ-irradia tion |
| Received:December 18, 2002 |
| DOI： |
| KeyWords:Tumor cell lines Radiation sensitivity Cell cycle arrest |
| FundProject:国家自然科学基金资助项目(39800149) |
| Author Name | Affiliation | | TANG Yi | The Hematology Department of Tongji Hospi tal, Tongji Medical College of Huazhong Science & Technology University, Wuhan 430030, China | | LIU Wenli | The Hematology Department of Tongji Hospi tal, Tongji Medical College of Huazhong Science & Technology University, Wuhan 430030, China | | ZHOU Jianfeng | The Hematology Department of Tongji Hospi tal, Tongji Medical College of Huazhong Science & Technology University, Wuhan 430030, China | | 高庆蕾 | The Hematology Department of Tongji Hospi tal, Tongji Medical College of Huazhong Science & Technology University, Wuhan 430030, China | | 吴剑宏 | The Hematology Department of Tongji Hospi tal, Tongji Medical College of Huazhong Science & Technology University, Wuhan 430030, China |
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| Abstract:: |
| Objective To observe the cell cycle arrest changes in peripheral blood mononuclear cells ( PBMNCs) of normal persons and several kinds of tumor cell lines after 60Coγ-irradiation. Methods PBMNCs of normal persons,HL-60,K562,SiHA and 113 tumor cell lines were irradiat ed with 60Coγ-rays at the absorbed doses of 6,10,15 Gy.Cell cycles changes were checked 6,12,24,48 and 60 h after the irradiation. Results A stasis state was observed in normal person PBMNCs, 95 p ercents of which were in G1 phase,and they still remained stasis after the irr adiation.Except the 113 cell line manifesting G1 phase arrest,all other tumor cell lines showed G2/M phase arrest after irradiation.The radiation sensitivit y of HL-60 was higher than that of SiHA cell line. Conclusion Different cell lines have different cell cycle arrest r eaction to radiation and their radiation sensitivity are also different. |
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